Team 4 - Sleep pathologies

Yves Dauvilliers

Sleep disorders, insomnia, excessive daytime somnolence and parasomnia are widespread in aged people. Sleep disorders may be considered as risk factors for psychiatric, neurological and cardiovascular diseases. The aim of our projects is to characterize sleep disorders within the 3-City cohort of elderly people at an epidemiological and polysomnographic (night sleep recording at home) level and to determine potential sleep risk factor for the modification of cardio-vascular and cognitive functions and mood. Ambulatory sleep recording is being carried out on a sub-group of persons in order to better describe prevalent sleep disorders, to determine their gravity and to observe interactions with other risk factors for neuropsychiatric disorder. The work conducted by this group aims furthermore to describe the mechanisms involved in the association between sleep disorders and clinical outcomes (cognition, cardiovascular function, motricity, mood) in order to initiate the first steps towards intervention aimed at reversible components of this pathway.

Neurologist
Professor

Statistician and Epidemiologist Senior Research Assistant Inserm

Neurologist, University Hospital Assistant, Ph D Student,  "Centre national de référence narcolepsie hypersomnie idiopathique"

Neurologist, Specialist assistant, "Médecin Neurologue, Assistante Spécialiste", le lieu "Centre national de référence narcolepsie hypersomnie idiopathique"

Psychiatrist Hospital Practitioner

Biostatistician Hospital personnel

Research Assistant Hospital Personnel, Neuropsychologist

Publications: 

Dauvilliers Y, Amulf I, Mignot E. Narcolepsy with cataplexy. Lancet 2007;369:499-511.
Tsuno N, Jaussent I, Dauvilliers Y, Touchon J, Ritchie K, Besset A. Determinants of excessive daytime sleepiness in a French community-dwelling elderly population. J Sleep Res 2007;16:364-71.
Empana JP, Dauvilliers Y, Dartigues JF, et al. Excessive Daytime Sleepiness Is an Independent Risk Indicator for Cardiovascular Mortality in Community-Dwelling Elderly The Three City Study. Stroke 2009;40:1219-24.
Billiard M, Jaussent I, Dauvilliers Y, Besset A. Recurrent hypersomnia: A review of 339 cases. Sleep Med Rev 2010.
Hor H, Kutalik Z, Dauvilliers Y, et al. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nature Genetics 2010;42:786-89.
Dauvilliers Y, Montplaisir J, Cochen V, et al. Post-H1N1 narcolepsy-cataplexy. Sleep 2010;33:1428-30.
Jaussent I, Dauvilliers Y, Ancelin ML, et al. Insomnia Symptoms in Older Adults: Associated Factors and Gender Differences. Am J Geriat Psychiat 2011;19:88-97.
Yu H, Laberge L, Jaussent I, et al. Daytime Sleepiness and REM Sleep Characteristics in Myotonic Dystrophy: A Case-Control Study. Sleep 2011;34:165-70.
Bayard S, Abril B, Yu H, Scholz S, Carlander B, Dauvilliers Y. Decision making in narcolepsy with cataplexy. Sleep 2011;34:99-104.
Cochen De Cock V, Debs R, Oudiette D, et al. The improvement of movement and speech during rapid eye movement sleep behaviour disorder in multiple system atrophy. Brain 2011;134:856-62.